Neurodegenerative diseases (NDs) are one of the major health threats to human
characterized by selective and progressive neuronal loss. The mechanisms of NDs are still …

Simple Summary DNA methylation is an epigenetic modification of genes which affects
corresponding gene expression. During the developmental stage, embryonic stem cells …

Evidence for epigenetic regulation playing a role in Parkinson's disease (PD) is growing,
particularly for DNA methylation. Approximately 90% of PD cases are due to a complex …

Parkinson's disease (PD) is a multifactorial disease due to a complex interplay between
genetic and epigenetic factors. Recent efforts shed new light on the epigenetic mechanisms …

It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects
of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative …

Importance Epigenetic modifications of the genome, such as DNA methylation and histone
modifications, have been reported to play a role in neurodegenerative diseases (ND) such …

Efforts have been made to understand the pathophysiology of Parkinson's disease (PD). A
significant number of studies have focused on genetics, despite the fact that the described …

Parkinson's disease (PD) is a disorder characterized by a triad of motor symptoms (akinesia,
rigidity, resting tremor) related to loss of dopaminergic neurons mainly in the Substantia …

Lewy body disorders (LBD) include Parkinson's disease (PD) and dementia with Lewy
bodies (DLB). They are synucleinopathies with a heterogeneous clinical manifestation. As a …

Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have
found that salidroside (Sal) exhibited neuroprotective effects against MPP+ toxicity …