[HTML][HTML] Vascular endothelial cell specification in health and disease
C Marziano, G Genet, KK Hirschi - Angiogenesis, 2021 - Springer
There are two vascular networks in mammals that coordinately function as the main supply
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …
and drainage systems of the body. The blood vasculature carries oxygen, nutrients …
[HTML][HTML] Future treatments for hereditary hemorrhagic telangiectasia
F Robert, A Desroches-Castan, S Bailly… - Orphanet journal of rare …, 2020 - Springer
Abstract Hereditary Hemorrhagic Telangiectasia (HHT), also known as Rendu-Osler
syndrome, is a genetic vascular disorder affecting 1 in 5000–8000 individuals worldwide …
syndrome, is a genetic vascular disorder affecting 1 in 5000–8000 individuals worldwide …
A single-cell atlas of the normal and malformed human brain vasculature
Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …
understanding of disease mechanisms and therapeutic strategies requires a deeper …
[HTML][HTML] SMAD4 maintains the fluid shear stress set point to protect against arterial-venous malformations
Vascular networks form, remodel, and mature under the influence of both fluid shear stress
(FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via …
(FSS) and soluble factors. Physiological FSS promotes and maintains vascular stability via …
Defective flow-migration coupling causes arteriovenous malformations in hereditary hemorrhagic telangiectasia
Background: Activin receptor-like kinase 1 (ALK1) is an endothelial transmembrane serine
threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular …
threonine kinase receptor for BMP family ligands that plays a critical role in cardiovascular …
[HTML][HTML] Arteriovenous malformations—current understanding of the pathogenesis with implications for treatment
Arteriovenous malformations are a vascular anomaly typically present at birth, characterized
by an abnormal connection between an artery and a vein (bypassing the capillaries). These …
by an abnormal connection between an artery and a vein (bypassing the capillaries). These …
Hereditary hemorrhagic telangiectasia: systemic therapies, guidelines, and an evolving standard of care
H Al-Samkari - Blood, The Journal of the American Society of …, 2021 - ashpublications.org
Hereditary hemorrhagic telangiectasia (HHT) management is evolving because of the
emergence and development of antiangiogenic therapies to eliminate bleeding …
emergence and development of antiangiogenic therapies to eliminate bleeding …
[HTML][HTML] MYBL1 induces transcriptional activation of ANGPT2 to promote tumor angiogenesis and confer sorafenib resistance in human hepatocellular carcinoma
J Zhu, Y Wu, Y Yu, Y Li, J Shen, R Zhang - Cell Death & Disease, 2022 - nature.com
Angiogenesis is considered as an important process in tumor growth, metastasis of
hepatocellular carcinoma (HCC) and associated with cancer progression, suggesting that …
hepatocellular carcinoma (HCC) and associated with cancer progression, suggesting that …
Endothelial GNAQ p.R183Q Increases ANGPT2 (Angiopoietin-2) and Drives Formation of Enlarged Blood Vessels
Objective: Capillary malformation (CM) occurs sporadically and is associated with Sturge-
Weber syndrome. The somatic mosaic mutation in GNAQ (c. 548G> A, p. R183Q) is enriched …
Weber syndrome. The somatic mosaic mutation in GNAQ (c. 548G> A, p. R183Q) is enriched …
[HTML][HTML] Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models
S Ruiz, H Zhao, P Chandakkar… - The Journal of …, 2020 - Am Soc Clin Investig
Hereditary hemorrhagic telangiectasia (HHT), a genetic bleeding disorder leading to
systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the …
systemic arteriovenous malformations (AVMs), is caused by loss-of-function mutations in the …