The enormous diversity of proteoforms produces tremendous complexity within cellular
proteomes, facilitates intricate networks of molecular interactions, and constitutes a …

Improved biomarkers are needed for early cancer detection, risk stratification, treatment
selection, and monitoring treatment response. Although proteins can be useful blood-based …

Bile acids (BAs) facilitate intestinal absorption of lipid-soluble nutrients and modulate
various metabolic pathways through the farnesoid X receptor (FXR) and Takeda G-protein …

Metabolic reprogramming is a hallmark of the immune cells in response to inflammatory
stimuli. This metabolic process involves a switch from oxidative phosphorylation (OXPHOS) …

Understanding the impact of various culturing strategies on the secretome composition of
adipose-derived stromal cells (ASC) enhances their therapeutic potential. This study …

Although transplantation of single genes in yeast plays a key role in elucidating gene
functionality in metazoans, technical challenges hamper humanization of full pathways and …

For mass spectrometry-based proteomics, the selected sample preparation strategy is a key
determinant for information that will be obtained. However, the corresponding selection is …

Diet modulates the development of insulin resistance during aging. This includes tissue-
specific alterations in insulin signaling and mitochondrial function, which ultimately affect …

Background The skeletal muscle plays a central role in glucose homeostasis through the
uptake of glucose from the extracellular medium in response to insulin. A number of factors …

Objective: STAP1, encoding for STAP1 (signal transducing adaptor family member 1), has
been reported as a candidate gene associated with familial hypercholesterolemia. Unlike …