Mendelian randomization: concepts and scope
RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …
Evaluating the potential role of pleiotropy in Mendelian randomization studies
Pleiotropy, the phenomenon of a single genetic variant influencing multiple traits, is likely
widespread in the human genome. If pleiotropy arises because the single nucleotide …
widespread in the human genome. If pleiotropy arises because the single nucleotide …
Assessment of bidirectional relationships between physical activity and depression among adults: a 2-sample Mendelian randomization study
Importance Increasing evidence shows that physical activity is associated with reduced risk
for depression, pointing to a potential modifiable target for prevention. However, the …
for depression, pointing to a potential modifiable target for prevention. However, the …
Using genetic data to strengthen causal inference in observational research
Causal inference is essential across the biomedical, behavioural and social sciences. By
progressing from confounded statistical associations to evidence of causal relationships …
progressing from confounded statistical associations to evidence of causal relationships …
GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal effect of schizophrenia liability
Cannabis use is a heritable trait that has been associated with adverse mental health
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
outcomes. In the largest genome-wide association study (GWAS) for lifetime cannabis use to …
Associations between prenatal cannabis exposure and childhood outcomes: results from the ABCD study
Importance In light of increasing cannabis use among pregnant women, the US Surgeon
General recently issued an advisory against the use of marijuana during pregnancy …
General recently issued an advisory against the use of marijuana during pregnancy …
Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates
S Burgess, JA Labrecque - European journal of epidemiology, 2018 - Springer
Mendelian randomization uses genetic variants to make causal inferences about a
modifiable exposure. Subject to a genetic variant satisfying the instrumental variable …
modifiable exposure. Subject to a genetic variant satisfying the instrumental variable …
Cannabis use and psychosis: a review of reviews
We conducted a systematic review of meta-analyses and systematic reviews to evaluate the
impact of cannabis use on the onset and course of psychoses. Following a systematic …
impact of cannabis use on the onset and course of psychoses. Following a systematic …
Environmental risk factors for schizophrenia and bipolar disorder and their relationship to genetic risk: current knowledge and future directions
N Robinson, SE Bergen - Frontiers in genetics, 2021 - frontiersin.org
Schizophrenia (SZ) and bipolar disorder (BD) are severe psychiatric disorders which result
from complex interplay between genetic and environmental factors. It is well-established that …
from complex interplay between genetic and environmental factors. It is well-established that …
Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study
Objectives To identify the genetic determinants of fracture risk and assess the role of 15
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …
clinical risk factors on osteoporotic fracture risk. Design Meta-analysis of genome wide …