▪ Abstract Meiotic chromosomes have been studied for many years, in part because of the
fundamental life processes they represent, but also because meiosis involves the formation …

Chromatin is the complex of DNA and proteins in which the genetic material is packaged
inside the cells of organisms with nuclei. Chromatin structure is dynamic and exerts …

The orderly progression of most DNA-related activities such as transcription, replication,
recombination, and repair involves changes in the structure of the DNA and in the …

Topoisomerase IIα (topoIIα) and 13S condensin are both required for mitotic chromosome
assembly. Here we show that they constitute the two main components of the chromosomal …

With the continuing accomplishments of the human genome project, high-throughput
strategies to identify DNA sequences that are important in mammalian gene regulation are …

Chromatin boundary activities (BAs) were identified in Saccharomyces cerevisiae by genetic
screening. Such BAs bound to sites flanking a reporter gene establish a nonsilenced …

The biological significance of nuclear scaffold/matrix-attachment regions (S/MARs) remains
a topic of long-standing interest. The key to understanding S/MAR behavior relies on …

The condensation of mitotic chromosomes is essential for the faithful segregation of sister
chromatids in anaphase. An emerging view is that chromosome assembly is an active and …

Matrix attachment regions (MARs) are operationally defined as DNA elements that bind
specifically to the nuclear matrix in vitro. It is possible, although unproven, that they also …

▪ Abstract The faithful segregation of genetic information requires highly orchestrated
changes of chromosome structure during the mitotic cell cycle. The linkage between …