Matrix metalloproteinases, vascular remodeling, and vascular disease
X Wang, RA Khalil - Advances in pharmacology, 2018 - Elsevier
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
degrade various proteins in the extracellular matrix (ECM). Typically, MMPs have a …
Matrix metalloproteinases in normal pregnancy and preeclampsia
J Chen, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Normal pregnancy is associated with marked hemodynamic and uterine changes that allow
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
adequate uteroplacental blood flow and uterine expansion for the growing fetus. These …
Conceptus-endometrium crosstalk during maternal recognition of pregnancy in cattle
S Mamo, JP Mehta, N Forde, P McGettigan… - Biology of …, 2012 - academic.oup.com
Successful growth and development of the posthatching blastocyst and pregnancy
establishment are a result of the interaction between a competent embryo and a receptive …
establishment are a result of the interaction between a competent embryo and a receptive …
Insights into the immunomodulatory regulation of matrix metalloproteinase at the maternal-fetal interface during early pregnancy and pregnancy-related diseases
M Jing, X Chen, H Qiu, W He, Y Zhou, D Li… - Frontiers in …, 2023 - frontiersin.org
Trophoblast immune cell interactions are central events in the immune microenvironment at
the maternal-fetal interface. Their abnormalities are potential causes of various pregnancy …
the maternal-fetal interface. Their abnormalities are potential causes of various pregnancy …
EMMPRIN-mediated induction of uterine and vascular matrix metalloproteinases during pregnancy and in response to estrogen and progesterone
Y Dang, W Li, V Tran, RA Khalil - Biochemical pharmacology, 2013 - Elsevier
Pregnancy is associated with uteroplacental and vascular remodeling in order to adapt for
the growing fetus and the hemodynamic changes in the maternal circulation. We have …
the growing fetus and the hemodynamic changes in the maternal circulation. We have …
Placental growth factor reverses decreased vascular and uteroplacental MMP-2 and MMP-9 and increased MMP-1 and MMP-7 and collagen types I and IV in …
Z Ren, N Cui, M Zhu, RA Khalil - American Journal of …, 2018 - journals.physiology.org
Preeclampsia is a complication of pregnancy manifested as maternal hypertension (HTN)
and fetal intrauterine growth restriction, with unclear mechanisms. Placental ischemia …
and fetal intrauterine growth restriction, with unclear mechanisms. Placental ischemia …
Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones
Z Yin, AA Sada, OM Reslan… - American Journal of …, 2012 - journals.physiology.org
Normal pregnancy is associated with uterine relaxation to accommodate the stretch imposed
by the growing fetus; however, the mechanisms underlying the relationship between …
by the growing fetus; however, the mechanisms underlying the relationship between …
Increased vascular and uteroplacental matrix metalloproteinase-1 and-7 levels and collagen type I deposition in hypertension in pregnancy: role of TNF-α
W Li, N Cui, MQ Mazzuca, KM Mata… - American Journal of …, 2017 - journals.physiology.org
Preeclampsia is a pregnancy-related disorder manifested as maternal hypertension in
pregnancy (HTN-Preg) and fetal growth restriction. Placental ischemia could be an initiating …
pregnancy (HTN-Preg) and fetal growth restriction. Placental ischemia could be an initiating …
Molecular determinants of microvascular dysfunction in hypertensive pregnancy and preeclampsia
W Yu, W Gao, D Rong, Z Wu, RA Khalil - Microcirculation, 2019 - Wiley Online Library
Preeclampsia is a pregnancy‐related disorder characterized by hypertension and often fetal
intrauterine growth restriction, but the underlying mechanisms are unclear. Defective …
intrauterine growth restriction, but the underlying mechanisms are unclear. Defective …
The potential function of endometrial‐secreted factors for endometrium remodeling during the estrous cycle
DH Billhaq, SH Lee, S Lee - Animal Science Journal, 2020 - Wiley Online Library
Uterine has a pivotal role in implantation and conceptus development. To prepare a
conducive uterine condition for possibly new gestation during the estrous cycle, uterine …
conducive uterine condition for possibly new gestation during the estrous cycle, uterine …