Toll-like receptors (TLRs) are a class of proteins that recognize pathogen-associated
molecular patterns (PAMPs) and damaged-associated molecular patterns (DAMPs), and …

Several synthetic heterocyclic small molecules like imiquimod, resiquimod, CL097, CL075,
bromopirone, tilorone, loxoribine and isatoribine demonstrated TLR7/8 agonistic activity and …

Summary Toll-like receptor 7 (TLR7) is an innate immune receptor for single-stranded RNA
(ssRNA) and has important roles in infectious diseases. We previously reported that TLR7 …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

The Toll-like receptors (TLRs) 7 and 8 play an important role in the immune system
activation, and their agonists may therefore serve as promising candidate vaccine adjuvants …

TLR7 agonists have significant therapeutic potential in a variety of oncology and
autoimmune applications. We recently reported a potent TLR7 selective agonist 1 that could …

Small molecule toll-like receptor (TLR) 7 agonists have gathered considerable interest as
promising therapeutic agents for applications in cancer immunotherapy. Herein, we describe …

Toll-like receptors (TLRs) 7 and 8 play an important role in the activation of innate immune
cells in mammals. These evolutionarily conserved receptors serve as important sentinels in …

TLR7/8 agonists are versatile immune stimulators capable of treating various diseases such
as viral infections, autoimmune, and cancer. Despite the structural similarity of TLR7/8, their …

Abstract Toll-like receptor (TLR) 7, a transmembrane signal transduction receptor expressed
on the surface of endosomes, has become an attractive target for antiviral and cancer …