Comparative oncology clinical trials play an important and growing role in cancer research
and drug development efforts. These trials, typically conducted in companion (pet) dogs …

Diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy
and the most common subtype of non-Hodgkin's lymphoma in adults, with one of the highest …

The two general groups for tumors of the hemolymphatic system are lymphoid (lymphoma
and leukemia) and myeloid leukemias. The tumors in each can be characterized by their …

The transformation of chronic lymphocytic leukemia (CLL) to high-grade B-cell lymphoma is
known as Richter syndrome (RS), a rare event with dismal prognosis. In this study, we …

Naturally occurring canine cancers have remarkable similarities to their human counterparts.
To better understand these similarities, we investigated 671 client-owned dogs from 96 …

Spontaneous cancers in client-owned dogs closely recapitulate their human counterparts
with respect to clinical presentation, histological features, molecular profiles, and response …

Spontaneous tumors in canines share significant genetic and histological similarities with
human tumors, positioning them as valuable models to guide drug development. However …

Tumor necrosis factor receptor–associated factor 3 (TRAF3) is a central regulator of
immunity. TRAF3 is often somatically mutated in B cell malignancies, but its role in human …

Lymphoma is the most common hematological malignancy in developed countries. Outcome
is strongly determined by molecular subtype, reflecting a need for new and improved …

Tumor necrosis factor receptor (TNFR)‐associated factors (TRAF s) form a family of proteins
that are best known as signaling adapters of TNFR s. However, emerging evidence …