Synonymous but not the same: the causes and consequences of codon bias
JB Plotkin, G Kudla - Nature Reviews Genetics, 2011 - nature.com
Despite their name, synonymous mutations have significant consequences for cellular
processes in all taxa. As a result, an understanding of codon bias is central to fields as …
processes in all taxa. As a result, an understanding of codon bias is central to fields as …
Tailor made: the art of therapeutic mRNA design
Abstract mRNA medicine is a new and rapidly developing field in which the delivery of
genetic information in the form of mRNA is used to direct therapeutic protein production in …
genetic information in the form of mRNA is used to direct therapeutic protein production in …
A new and updated resource for codon usage tables
J Athey, A Alexaki, E Osipova, A Rostovtsev… - BMC …, 2017 - Springer
Background Due to the degeneracy of the genetic code, most amino acids can be encoded
by multiple synonymous codons. Synonymous codons naturally occur with different …
by multiple synonymous codons. Synonymous codons naturally occur with different …
The green fluorescent protein
RY Tsien - Annual review of biochemistry, 1998 - annualreviews.org
In just three years, the green fluorescent protein (GFP) from the jellyfish Aequorea victoria
has vaulted from obscurity to become one of the most widely studied and exploited proteins …
has vaulted from obscurity to become one of the most widely studied and exploited proteins …
[HTML][HTML] Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
F Doetsch, I Caille, DA Lim, JM García-Verdugo… - Cell, 1999 - cell.com
Neural stem cells reside in the subventricular zone (SVZ) of the adult mammalian brain. This
germinal region, which continually generates new neurons destined for the olfactory bulb, is …
germinal region, which continually generates new neurons destined for the olfactory bulb, is …
[HTML][HTML] Fluorescent indicators for Ca2+based on green fluorescent proteins and calmodulin
Important Ca2+ signals in the cytosol and organelles are often extremely localized and hard
to measure. To overcome this problem we have constructed new fluorescent indicators for …
to measure. To overcome this problem we have constructed new fluorescent indicators for …
Codon bias and heterologous protein expression
C Gustafsson, S Govindarajan, J Minshull - Trends in biotechnology, 2004 - cell.com
The expression of functional proteins in heterologous hosts is a cornerstone of modern
biotechnology. Unfortunately, proteins are often difficult to express outside their original …
biotechnology. Unfortunately, proteins are often difficult to express outside their original …
Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield
S Zolotukhin, BJ Byrne, E Mason, I Zolotukhin, M Potter… - Gene therapy, 1999 - nature.com
Conventional methods for rAAV purification that are based on cesium chloride
ultracentrifugation have often produced vector preparations of variable quality and resulted …
ultracentrifugation have often produced vector preparations of variable quality and resulted …
In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses
Adeno-associated virus (AAV) serotypes differ broadly in transduction efficacies and tissue
tropisms and thus hold enormous potential as vectors for human gene therapy. In reality …
tropisms and thus hold enormous potential as vectors for human gene therapy. In reality …
Removal of a cryptic intron and subcellular localization of green fluorescent protein are required to mark transgenic Arabidopsis plants brightly
J Haseloff, KR Siemering… - Proceedings of the …, 1997 - National Acad Sciences
The green fluorescent protein (GFP) from the jellyfish Aequorea victoria is finding wide use
as a genetic marker that can be directly visualized in the living cells of many heterologous …
as a genetic marker that can be directly visualized in the living cells of many heterologous …