Gene drives are selfish genetic elements that are transmitted to progeny at super-Mendelian
(> 50%) frequencies. Recently developed CRISPR–Cas9-based gene-drive systems are …

Mosquito-borne diseases, such as dengue and malaria, pose a significant burden to global
health. Current control strategies with insecticides are only moderately effective. Scalable …

Engineered gene drives based on a homing mechanism could rapidly spread genetic
alterations through a population. However, such drives face a major obstacle in the form of …

Genetic biocontrol aims to suppress or modify populations of species to protect public
health, agriculture, and biodiversity. Advancements in genome engineering technologies …

Gene drive technology, in which fast‐spreading engineered drive alleles are introduced into
wild populations, represents a promising new tool in the fight against vector‐borne diseases …

Background CRISPR gene drive systems allow the rapid spread of a genetic construct
throughout a population. Such systems promise novel strategies for the management of …

Invasive rodent populations pose a threat to biodiversity across the globe. When confronted
with these invaders, native species that evolved independently are often defenseless …

Genetic control strategies such as the sterile insect technique have successfully fought
insect pests worldwide. The CRISPR (clustered regularly interspaced short palindromic …

The spread of synthetic gene drives is often discussed in the context of panmictic
populations connected by gene flow and described with simple deterministic models. Under …

Optimism regarding potential epidemiological and conservation applications of modern
gene drives is tempered by concern about the possibility of unintended spread of …