Reproducible, scalable, and shareable analysis pipelines with bioinformatics workflow managers
The rapid growth of high-throughput technologies has transformed biomedical research.
With the increasing amount and complexity of data, scalability and reproducibility have …
With the increasing amount and complexity of data, scalability and reproducibility have …
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas
Abstract Canonical (H3. 1/H3. 2) and noncanonical (H3. 3) histone 3 K27M-mutant gliomas
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
have unique spatiotemporal distributions, partner alterations and molecular profiles. The …
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
Prostate cancers are considered to be immunologically 'cold'tumors given the very few
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
patients who respond to checkpoint inhibitor (CPI) therapy. Recently, enrichment of …
[HTML][HTML] Histone H3. 3G34-mutant interneuron progenitors co-opt PDGFRA for gliomagenesis
Summary Histone H3. 3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
gliomas and show exquisite regional and temporal specificity, suggesting a developmental …
Big data in biology: the hope and present-day challenges in it
The wave of new technologies has opened up the opportunity for cost-effective generation of
high-throughput profiles of biological systems. This is generating tons of biological data. It is …
high-throughput profiles of biological systems. This is generating tons of biological data. It is …
Epigenetic variation impacts individual differences in the transcriptional response to influenza infection
Humans display remarkable interindividual variation in their immune response to identical
challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such …
challenges. Yet, our understanding of the genetic and epigenetic factors contributing to such …
High‐efficiency delivery of CRISPR‐Cas9 by engineered probiotics enables precise microbiome editing
K Neil, N Allard, P Roy, F Grenier… - Molecular systems …, 2021 - embopress.org
Antibiotic resistance threatens our ability to treat infectious diseases, spurring interest in
alternative antimicrobial technologies. The use of bacterial conjugation to deliver CRISPR …
alternative antimicrobial technologies. The use of bacterial conjugation to deliver CRISPR …
Single substitution in H3. 3G34 alters DNMT3A recruitment to cause progressive neurodegeneration
Germline histone H3. 3 amino acid substitutions, including H3. 3G34R/V, cause severe
neurodevelopmental syndromes. To understand how these mutations impact brain …
neurodevelopmental syndromes. To understand how these mutations impact brain …
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
A well-functioning placenta is essential for fetal and maternal health throughout pregnancy.
Using placental weight as a proxy for placental growth, we report genome-wide association …
Using placental weight as a proxy for placental growth, we report genome-wide association …
Establishment of paternal methylation imprint at the H19/Igf2 imprinting control region
J Liao, S Song, S Gusscott, Z Fu, I VanderKolk… - Science …, 2023 - science.org
The insulator model explains the workings of the H19 and Igf2 imprinted domain in the
soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the …
soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the …