Recent advances in multicellular tumor spheroid generation for drug screening

KH Lee, TH Kim - Biosensors, 2021 - mdpi.com
Multicellular tumor spheroids (MCTs) have been employed in biomedical fields owing to
their advantage in designing a three-dimensional (3D) solid tumor model. For controlling …

[HTML][HTML] Construction and application of liver cancer models in vitro

C Shao, Q Zhang, G Kuang, Q Fan, F Ye - Engineered Regeneration, 2022 - Elsevier
Primary liver cancer is the fifth most common malignancy and the third leading cause of
cancer death worldwide. Although current advances in the treatment of liver cancer, the …

Production of multiple cell‐laden microtissue spheroids with a biomimetic hepatic‐lobule‐like structure

G Hong, J Kim, H Oh, S Yun, CM Kim… - Advanced …, 2021 - Wiley Online Library
The construction of an in vitro 3D cellular model to mimic the human liver is highly desired
for drug discovery and clinical applications, such as patient‐specific treatment and cell …

Sub-wavelength acoustic stencil for tailored micropatterning

K Kolesnik, P Segeritz, DJ Scott, V Rajagopal… - Lab on a Chip, 2023 - pubs.rsc.org
Acoustofluidic devices are ideal for biomedical micromanipulation applications, with high
biocompatibility and the ability to generate force gradients down to the scale of cells …

Fabrication of size-controllable and arrangement-orderly HepG2 spheroids for drug screening via decellularized liver matrix-derived micropattern array chips

X Zhu, Q Wu, Y He, M Gao, Y Li, W Peng, S Li, Y Liu… - ACS …, 2022 - ACS Publications
Three-dimensional (3D) culture via micropattern arrays to generate cellular spheroids
seems a promising in vitro biomimetic system for liver tissue engineering applications, such …

Nano-sized graphene oxide coated nanopillars on microgroove polymer arrays that enhance skeletal muscle cell differentiation

HK Choi, CH Kim, SN Lee, TH Kim, BK Oh - Nano Convergence, 2021 - Springer
The degeneration or loss of skeletal muscles, which can be caused by traumatic injury or
disease, impacts most aspects of human activity. Among various techniques reported to …

Three-dimensional microtumor formation of infantile hemangioma-derived endothelial cells for mechanistic exploration and drug screening

Y Li, X Zhu, M Kong, S Chen, J Bao, Y Ji - Pharmaceuticals, 2022 - mdpi.com
Infantile hemangioma (IH) is the most prevalent type of vascular tumor in infants. The
pathophysiology of IH is unknown. The tissue structure and physiology of two-dimensional …

Infantile hemangioma models: is the needle in a haystack?

M Kong, Y Li, K Wang, S Zhang, Y Ji - Journal of translational medicine, 2023 - Springer
Infantile hemangioma (IH) is the most prevalent benign vascular tumor in infants, with
distinct disease stages and durations. Despite the fact that the majority of IHs can regress …

Gold nanostructure-integrated conductive microwell arrays for uniform cancer spheroid formation and electrochemical drug screening

FN Ju, CH Kim, KH Lee, CD Kim, J Lim, T Lee… - Biosensors and …, 2023 - Elsevier
Cancer spheroids, which mimic distinct cell-to-cell and cell-extracellular matrix interactions
of solid tumors in vitro, have emerged as a promising tumor model for drug screening …

Graphene Oxide Nanoparticles and Organoids: A Prospective Advanced Model for Pancreatic Cancer Research

S Mai, I Inkielewicz-Stepniak - International Journal of Molecular Sciences, 2024 - mdpi.com
Pancreatic cancer, notorious for its grim 10% five-year survival rate, poses significant clinical
challenges, largely due to late-stage diagnosis and limited therapeutic options. This review …