Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

The interplay between vitamin D and viral infections

M Teymoori‐Rad, F Shokri, V Salimi… - Reviews in medical …, 2019 - Wiley Online Library
The pleiotropic role of vitamin D has been explored over the past decades and there is
compelling evidence for an epidemiological association between poor vitamin D status and …

Human antimicrobial peptides as therapeutics for viral infections

A Ahmed, G Siman-Tov, G Hall, N Bhalla, A Narayanan - Viruses, 2019 - mdpi.com
Successful in vivo infection following pathogen entry requires the evasion and subversion of
multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune …

Antimicrobial mechanisms and clinical application prospects of antimicrobial peptides

X Li, S Zuo, B Wang, K Zhang, Y Wang - Molecules, 2022 - mdpi.com
Antimicrobial peptides are a type of small-molecule peptide that widely exist in nature and
are components of the innate immunity of almost all living things. They play an important role …

A comprehensive summary of LL-37, the factotum human cathelicidin peptide

D Vandamme, B Landuyt, W Luyten, L Schoofs - Cellular immunology, 2012 - Elsevier
Cathelicidins are a group of antimicrobial peptides. Since their discovery, it has become
clear that they are an exceptional class of peptides, with some members having pleiotropic …

Immunomodulatory role of the antimicrobial LL-37 peptide in autoimmune diseases and viral infections

B Pahar, S Madonna, A Das, C Albanesi, G Girolomoni - Vaccines, 2020 - mdpi.com
Antimicrobial peptides (AMPs) are produced by neutrophils, monocytes, and macrophages,
as well as epithelial cells, and are an essential component of innate immunity system …

Design of antimicrobial peptides: progress made with human cathelicidin LL-37

G Wang, JL Narayana, B Mishra, Y Zhang… - … Peptides: Basics for …, 2019 - Springer
The incorporation of the innate immune system into humans is essential for survival and
health due to the rapid replication of invading microbes and the delayed action of the …

Perspectives for clinical use of engineered human host defense antimicrobial peptides

ME Pachón-Ibáñez, Y Smani, J Pachon… - FEMS microbiology …, 2017 - academic.oup.com
Infectious diseases caused by bacteria, viruses or fungi are among the leading causes of
death worldwide. The emergence of drug-resistance mechanisms, especially among …

[HTML][HTML] High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

G Wang, B Mishra, RF Epand, RM Epand - Biochimica et Biophysica Acta …, 2014 - Elsevier
Host defense antimicrobial peptides are key components of human innate immunity that
plays an indispensible role in human health. While there are multiple copies of cathelicidin …

The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus

SM Currie, EG Findlay, BJ McHugh, A Mackellar… - PloS one, 2013 - journals.plos.org
Respiratory syncytial virus is a leading cause of lower respiratory tract illness among infants,
the elderly and immunocompromised individuals. Currently, there is no effective vaccine or …