[HTML][HTML] Circular RNAs: Characterization, cellular roles, and applications

CX Liu, LL Chen - Cell, 2022 - cell.com
Most circular RNAs are produced from the back-splicing of exons of precursor mRNAs.
Recent technological advances have in part overcome problems with their circular …

Coding, or non-coding, that is the question

L Poliseno, M Lanza, PP Pandolfi - Cell Research, 2024 - nature.com
The advent of high-throughput sequencing uncovered that our genome is pervasively
transcribed into RNAs that are seemingly not translated into proteins. It was also found that …

Circular RNA encoded MET variant promotes glioblastoma tumorigenesis

J Zhong, X Wu, Y Gao, J Chen, M Zhang… - Nature …, 2023 - nature.com
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …

A novel protein encoded by exosomal CircATG4B induces oxaliplatin resistance in colorectal cancer by promoting autophagy

Z Pan, J Zheng, J Zhang, J Lin, J Lai, Z Lyu… - Advanced …, 2022 - Wiley Online Library
Oxaliplatin is commonly used in chemotherapeutic regimens for colorectal cancer (CRC)
after surgical resection. However, acquired chemoresistance seriously affects the curative …

Circular RNA translation: novel protein isoforms and clinical significance

S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

Understanding the roles and regulation patterns of circRNA on its host gene in tumorigenesis and tumor progression

J Wei, M Li, C Xue, S Chen, L Zheng, H Deng… - Journal of Experimental …, 2023 - Springer
Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are
covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back …

Circular EZH2-encoded EZH2-92aa mediates immune evasion in glioblastoma via inhibition of surface NKG2D ligands

J Zhong, X Yang, J Chen, K He, X Gao, X Wu… - Nature …, 2022 - nature.com
Glioblastoma (GBM) is a highly aggressive primary brain tumour and is resistant to nearly all
available treatments, including natural killer (NK) cell immunotherapy. However, the factors …

Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …

[PDF][PDF] IL‐6–induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma

H Li, T Lan, H Liu, C Liu, J Dai, L Xu, Y Cai, G Hou… - …, 2022 - Wiley Online Library
Background and Aims IL‐6–induced tumor progression has been well established through
the induction of antiapoptotic and proliferative genes. However, whether other mechanisms …

[HTML][HTML] CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer

J Zhang, S Chen, S Wei, S Cheng, R Shi, R Zhao… - Redox Biology, 2022 - Elsevier
Endometrial cancer (EC) is one of the most common gynecological cancers. Ferroptosis is a
newly identified form of cell death characterized by iron-dependent lipid peroxide …