Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique
biophysical properties: a small headgroup; negative charge; and a phosphomonoester …

Skeletal muscle hypertrophy can be induced by hormones and growth factors acting directly
as positive regulators of muscle growth or indirectly by neutralizing negative regulators, and …

Long noncoding RNAs (lncRNAs) are emerging as a new class of important regulators of
signal transduction in tissue homeostasis and cancer development. Liquid–liquid phase …

The Hippo pathway is known for its crucial involvement in development, regeneration, organ
size control, and cancer. While energy stress is known to activate the Hippo pathway and …

Lipids function not only as the major structural components of cell membranes, but also as
molecular messengers that transduce signals to trigger downstream signaling events in the …

Heavy metals are both integral parts of cells and environmental toxicants, and their
deregulation is associated with severe cellular dysfunction and various diseases. Here we …

Phosphoinositides are essential signaling molecules. The PI5P4K family of
phosphoinositide kinases and their substrates and products, PI5P and PI4, 5P2 …

Merlin/NF2 is a bona fide tumor suppressor whose mutations underlie inherited tumor
syndrome neurofibromatosis type 2 (NF2), as well as various sporadic cancers including …

Iron metabolism dysregulation is tightly associated with cancer development. But the
underlying mechanisms remain poorly understood. Increasing evidence has shown that …

Breast cancer (BC) is one of the most prominent diseases in the world, and the treatments
for BC have many limitations, such as resistance and a lack of reliable biomarkers. Currently …