Ras-GTPase-activating protein-binding protein 1 (G3BP1) is a core component and crucial
regulatory switch in stress granules (SGs). When the concentration of free RNA within cells …

Assessing the impact of SARS-CoV-2 on organelle dynamics allows a better understanding
of the mechanisms of viral replication. We combine label-free holotomographic microscopy …

Introduction Lower respiratory tract infections (LRTI) remain a significant global cause of
mortality and disability. Viruses constitute a substantial proportion of LRTI cases, with their …

Respiratory syncytial virus (RSV) is a global healthcare problem, causing respiratory illness
in young children and elderly individuals. Our knowledge of the host pathways that define …

Japanese encephalitis virus (JEV) is an arthropod-borne, plus-strand flavivirus causing viral
encephalitis in humans with a high case fatality rate. The JEV non-structural protein 5 (NS5) …

In recent years, the role of liquid–liquid phase separation (LLPS) and intrinsically disordered
proteins (IDPs) in cellular molecular processes has received increasing attention from …

A defining feature of a productive viral infection is the co-opting of host cell resources for
viral replication. Despite the host repertoire of molecular functions and biological counter …

During the COVID-19 pandemic, RNA-seq datasets were produced to investigate the virus–
host relationship. However, much of these data remains underexplored. To improve the …

The nucleocapsid (N) protein of coronaviruses is a structural protein that binds viral RNA for
assembly into the mature virion, a process that occurs in the cytoplasm. Several coronavirus …

Many viruses target the host nuclear transport machinery to traffic their own proteins or
restrict trafficking of host cargo, including mediators of antiviral immune signalling …