Group A streptococci are model extracellular gram-positive pathogens responsible for
pharyngitis, impetigo, rheumatic fever, and acute glomerulonephritis. A resurgence of …

Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Recent work from several laboratories has demonstrated that proteolytic mechanisms
significantly contribute to the molecular interplay between Streptococcus pyogenes, an …

Streptococcus pyogenes is an important human pathogen that selectively interacts with
proteins involved in the humoral defense system, such as immunoglobulins and …

The group A streptococcus (GAS)(Streptococcus pyogenes) is among the most common and
versatile of human pathogens. It is responsible for a wide spectrum of human diseases …

Effectors of the innate immune system, the anti‐bacterial peptides, have pivotal roles in
preventing infection at epithelial surfaces. Here we show that proteinases of the significant …

Objective. To determine the most effective antibiotic treatment for invasive S. pyogenes
infection in humans. Design and setting. We conducted a retrospective review of the …

Group A streptococcus (Streptococcus pyogenes) is an exclusively human pathogen that
causes a wide spectrum of diseases ranging from pharyngitis, to impetigo, to toxic shock, to …

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as
well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades …

Considerable insight has been gained into the etiopathogenesis of poststreptococcal
glomerulonephritis since the landmark theoretical construct of Clemens von Pirquet …