Major depression is one of the most prevalent and debilitating personal and public health
conditions worldwide. Less appreciated is that depression's tremendous burdens are not …

Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …

BackgroundSouth Africa's national lockdown introduced serious threats to public mental
health in a society where one in three individuals develops a psychiatric disorder during …

We propose that depression can be viewed as an adaptation to conserve energy after the
perceived loss of an investment in a vital resource such as a relationship, group identity, or …

Background: Exposure to demands is normally considered to drain resources and threaten
wellbeing. However, studies have indicated a resilience-strengthening role for stressors …

Depression presents in roughly 20% of people with diabetes worldwide, and adversely
affects quality of life and treatment outcomes. The causes of depression in diabetes are …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

Stress generation theory initially posited that depression elevates risk for some stressful
events (ie, dependent events) but not others (ie, independent events). This preregistered …

Background Longitudinal studies of illness progression in patients with major depressive
disorder (MDD) indicate that the onset of subsequent depressive episodes becomes …

I have been given a priceless opportunity to reflect on my career in the remarkably
productive field of risk factors for depression. Psychological research on depression …