Mesolimbic dopamine release conveys causal associations

H Jeong, A Taylor, JR Floeder, M Lohmann, S Mihalas… - Science, 2022 - science.org
Learning to predict rewards based on environmental cues is essential for survival. It is
believed that animals learn to predict rewards by updating predictions whenever the …

[HTML][HTML] Dopamine dysregulation in reward and autism spectrum disorder

K Blum, A Bowirrat, K Sunder, PK Thanos, C Hanna… - Brain Sciences, 2024 - mdpi.com
Autism spectrum disorder (ASD) is primarily characterized by core deficits in social skills,
communication, and cognition and by repetitive stereotyped behaviors. These …

Ventral pallidum GABA and glutamate neurons drive approach and avoidance through distinct modulation of VTA cell types

L Faget, L Oriol, WC Lee, V Zell, C Sargent… - Nature …, 2024 - nature.com
The ventral pallidum (VP) contains GABA and glutamate neurons projecting to ventral
tegmental area (VTA) whose stimulation drives approach and avoidance, respectively. Yet …

From prediction to action: dissociable roles of ventral tegmental area and substantia nigra dopamine neurons in instrumental reinforcement

KM Fraser, HJ Pribut, PH Janak… - Journal of …, 2023 - Soc Neuroscience
Reward seeking requires the coordination of motor programs to achieve goals. Midbrain
dopamine neurons are critical for reinforcement, and their activation is sufficient for learning …

[HTML][HTML] What role does striatal dopamine play in goal-directed action?

G Hart, TJ Burton, BW Balleine - Neuroscience, 2024 - Elsevier
Evidence suggests that dopamine activity provides a US-related prediction error for
Pavlovian conditioning and the reinforcement signal supporting the acquisition of habits …

Dopamine neurons drive spatiotemporally heterogeneous striatal dopamine signals during learning

L Engel, AR Wolff, M Blake, VL Collins, S Sinha… - Current Biology, 2024 - cell.com
Environmental cues, through Pavlovian learning, become conditioned stimuli that invigorate
and guide animals toward rewards. Dopamine (DA) neurons in the ventral tegmental area …

Cognitive representations of intracranial self-stimulation of midbrain dopamine neurons depend on stimulation frequency

SJ Millard, IB Hoang, S Sherwood, M Taira… - Nature …, 2024 - nature.com
Dopamine neurons in the ventral tegmental area support intracranial self-stimulation (ICSS),
yet the cognitive representations underlying this phenomenon remain unclear. Here, 20-Hz …

Mesolimbic dopamine adapts the rate of learning from action

LT Coddington, SE Lindo, JT Dudman - Nature, 2023 - nature.com
Recent success in training artificial agents and robots derives from a combination of direct
learning of behavioural policies and indirect learning through value functions,–. Policy …

Does phasic dopamine release cause policy updates?

F Carter, MP Cossette, I Trujillo‐Pisanty… - European Journal of …, 2024 - Wiley Online Library
Phasic dopamine activity is believed to both encode reward‐prediction errors (RPEs) and to
cause the adaptations that these errors engender. If so, a rat working for optogenetic …

Nucleus accumbens and dorsal medial striatal dopamine and neural activity are essential for action sequence performance

KM Fraser, BJ Chen, PH Janak - European Journal of …, 2024 - Wiley Online Library
Separable striatal circuits have unique functions in Pavlovian and instrumental behaviors
but how these roles relate to performance of sequences of actions with and without …