Ion channels play a central role in the regulation of nearly every cellular process. Dating
back to the classic 1952 Hodgkin–Huxley model of the generation of the action potential, ion …

Pathological fear and anxiety are highly debilitating and, despite considerable advances in
psychotherapy and pharmacotherapy they remain insufficiently treated in many patients with …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

The basis for selective death of specific neuronal populations in neurodegenerative
diseases remains unclear. Parkinson's disease (PD) is a synucleinopathy characterized by a …

Parkinson's disease (PD) is the second most common neurodegenerative disease in the
world. Its causes are poorly understood and there is no proven therapeutic strategy for …

Large-scale genome-wide association studies have consistently shown that genetic
variation in CACNA1C, a gene that encodes calcium voltage-gated channel subunit …

Across all kingdoms in the tree of life, calcium (Ca2+) is an essential element used by cells
to respond and adapt to constantly changing environments. In multicellular organisms, it …

This review addresses the localized regulation of voltage-gated ion channels by
phosphorylation. Comprehensive data on channel regulation by associated protein kinases …

Significance: Parkinson's disease (PD) is a neurodegenerative disorder characterized, in
part, by the progressive and selective loss of dopaminergic neuron cell bodies within the …

Dopamine‐releasing neurons within the Substantia nigra (SN DA) are particularly
vulnerable to degeneration compared to other dopaminergic neurons. The age‐dependent …