Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
In vitro Models of Neurodegenerative Diseases
A Slanzi, G Iannoto, B Rossi, E Zenaro… - Frontiers in cell and …, 2020 - frontiersin.org
Neurodegenerative diseases are progressive degenerative conditions characterized by the
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
functional deterioration and ultimate loss of neurons. These incurable and debilitating …
Metabolically driven maturation of human-induced-pluripotent-stem-cell-derived cardiac microtissues on microfluidic chips
The immature physiology of cardiomyocytes derived from human induced pluripotent stem
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
cells (hiPSCs) limits their utility for drug screening and disease modelling. Here we show …
Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes
The functions of the heart are achieved through coordination of different cardiac cell
subtypes (eg, ventricular, atrial, conduction-tissue cardiomyocytes). Human pluripotent stem …
subtypes (eg, ventricular, atrial, conduction-tissue cardiomyocytes). Human pluripotent stem …
Unraveling the mechanistic effects of electric field stimulation towards directing stem cell fate and function: A tissue engineering perspective
Electric field (EF) stimulation can play a vital role in eliciting appropriate stem cell response.
Such an approach is recently being established to guide stem cell differentiation through …
Such an approach is recently being established to guide stem cell differentiation through …
Engineering adolescence: maturation of human pluripotent stem cell–derived cardiomyocytes
X Yang, L Pabon, CE Murry - Circulation research, 2014 - Am Heart Assoc
The discovery of human pluripotent stem cells (hPSCs), including both human embryonic
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
stem cells and human-induced pluripotent stem cells, has opened up novel paths for a wide …
Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions
The protocol described here efficiently directs human pluripotent stem cells (hPSCs) to
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
functional cardiomyocytes in a completely defined, growth factor–and serum-free system by …
Human induced pluripotent stem cell–derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes
Disease models are essential for understanding cardiovascular disease pathogenesis and
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
developing new therapeutics. The human induced pluripotent stem cell (iPSC) technology …
Biowire: a platform for maturation of human pluripotent stem cell–derived cardiomyocytes
Directed differentiation protocols enable derivation of cardiomyocytes from human
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
pluripotent stem cells (hPSCs) and permit engineering of human myocardium in vitro …
Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling
Human pluripotent stem cells (hPSCs) offer the potential to generate large numbers of
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …
functional cardiomyocytes from clonal and patient-specific cell sources. Here we show that …