Copper (I)-catalyzed 1, 3-dipolar cycloaddition between organic azides and terminal
alkynes, commonly known as CuAAC or click chemistry, has been identified as one of the …

Cu (I)-catalyzed azide–alkyne 1, 3-dipolar cycloaddition (CuAAC), popularly known as the
“click reaction”, serves as the most potent and highly dependable tool for facile construction …

One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

Complex organisms have evolved from a limited number of primordial genes and proteins.
However, the mechanisms by which the earliest proteins evolved and then served as the …

Sialic acids are a family of negatively charged monosaccharides which are commonly
presented as the terminal residues in glycans of the glycoconjugates on eukaryotic cell …

Sialic acids are acidic monosaccharides, which are among the most important molecules of
higher animals, and occur in some microorganisms. They are bound to complex …

The surface of the protozoan parasite Trypanosoma cruzi is covered in mucins, which
contribute to parasite protection and to the establishment of a persistent infection. Their …

Carbohydrates are ubiquitous in Nature and play vital roles in many biological systems.
Therefore the synthesis of carbohydrate-based compounds is of considerable interest for …

Enzymes that catalyse the synthesis and breakdown of glycosidic bonds account for 1–3%
of the proteins encoded by the genomes of most organisms. At the current rate, over 12 000 …

Sialic acids consist of a family of acidic ninecarbon sugars that are typically located at the
terminal positions of a variety of glycoconjugates. Naturally occurring sialic acids show an …