Pituitary adenomas are one of the most frequent intracranial tumors and occur with a
prevalence of approximately 1: 1000 in the developed world. Pituitary adenomas have a …

Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary
adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of …

Context: Familial isolated pituitary adenoma (FIPA) due to aryl hydrocarbon receptor
interacting protein (AIP) gene mutations is an autosomal dominant disease with incomplete …

Cyclooxygenase-2 (COX-2) is associated with breast tumour progression. Clinical and
molecular studies implicate human epidermal growth factor receptor 2 (HER2) in the …

Context: Pituitary adenomas and pheochromocytomas/paragangliomas (pheo/PGL) can
occur in the same patient or in the same family. Coexistence of the two diseases could be …

Role of growth hormone (GH) in mammalian aging is actively explored in clinical,
epidemiological, and experimental studies. The age-related decline in GH levels is variously …

Context: Germline mutations of the AIP (aryl-hydrocarbon receptor interacting protein) gene
are associated with a predisposition to pituitary adenomas. Such mutations are found in …

Acromegaly is a chronic disease with increased morbidity and mortality, where usually
multiple treatment modalities are used. The somatostatin analogs (SSAs) are the mainstay of …

Context: Somatotroph adenomas harboring aryl hydrocarbon receptor interacting protein
(AIP) mutations respond less well to somatostatin analogs, suggesting that the effects of …