Depression is the most common mental disorder and a leading cause of disability
worldwide. Despite abundant research, the precise mechanisms underlying the …

The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

Worldwide, and especially in Western civilizations, most of the staple diets contain high
amounts of fat and refined carbohydrates, leading to an increasing number of obese …

Background: Obesity is becoming a global epidemic and reversing the pathological
processes underlying obesity and metabolic co-morbidities is challenging. Obesity induced …

Depression is one of the most common mental illnesses in modern society. In recent years,
several studies show that there are disturbances in lipid metabolism in depressed patients …

High-fat diet (HFD) consumption is generally associated with an increased risk of cognitive
and emotional dysfunctions that constitute a sizeable worldwide health burden with …

Neuropsychiatric disorders, including anxiety and depression, are one of the most common
mental illnesses worldwide. A growing body of evidence shows that there is a complex …

Western societies experienced drastic changes in eating habits during the past century. The
modern nutritional profile, typically rich in saturated fats and refined sugars, is recognized as …

Comorbidity exists between metabolic disorders and depressive syndrome with unclear
mechanisms. To characterize the causal relationship, we adopted a 12-week high-fat diet …

Background: Timely and complete restoration of blood flow is the most effective intervention
for patients with acute myocardial infarction. However, the efficacy is limited by myocardial …