Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

Myopia, also known as short-sightedness or near-sightedness, is a very common condition
that typically starts in childhood. Severe forms of myopia (pathologic myopia) are associated …

The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …

The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …

Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …

Several epidemiological observations have shown an inverse relation between
consumption of plant-based foods, rich in phytochemicals, and incidence of cancer …

NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective
functions are deemed to be the main cellular defense mechanism against exogenous and …

Abstract Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against
environmental stresses. Nrf2 induces the expression of detoxification and antioxidant …

Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Organismal life encounters reactive oxidants from internal metabolism and environmental
toxicant exposure. Reactive oxygen and nitrogen species cause oxidative stress and are …