Prospective epidemiological studies have consistently demonstrated that cannabis use is
associated with an increased subsequent risk of both psychotic symptoms and …

Opioid addiction is a chronic and complex disease characterized by relapse and remission.
In the past decade, the opioid epidemic or opioid crisis in the United States has raised public …

Chronic kidney disease (CKD) is a common complex condition associated with high
morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; …

Substance use disorders (SUDs) are highly prevalent and exact a large toll on individuals'
health, well‐being, and social functioning. Long‐lasting changes in brain networks involved …

Chronic kidney disease (CKD) is determined by an interplay of monogenic, polygenic, and
environmental risks. Autosomal dominant polycystic kidney disease (ADPKD) and COL4A …

Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …

Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50
million people worldwide. Our understanding of the genetic etiology of BD has greatly …

Genomewide association studies (GWASs) across psychiatric phenotypes have shown that
common genetic variants generally confer risk with small effect sizes (odds ratio< 1.1) that …

Cannabis is the most frequently used illicit psychoactive substance worldwide; around one
in ten users become dependent. The risk for cannabis use disorder (CUD) has a strong …

The last decade brought tremendous progress in the field of schizophrenia genetics. As a
result of extensive collaborations and multiple technological advances, we now recognize …