The burden of human disease associated with fungal infections is generally
underappreciated, with estimates indicating as many as 150 million persons infected …

Fungal pathogens use various mechanisms to survive exposure to drugs. Prolonged
treatment very often leads to the stepwise acquisition of resistance. The limited number of …

Sterol traffic between the endoplasmic reticulum (ER) and plasma membrane (PM) is a
fundamental cellular process that occurs by a poorly understood non-vesicular mechanism …

Candida albicans causes superficial and life-threatening systemic infections. These are
difficult to treat often due to drug resistance, particularly because C. albicans biofilms are …

Fungal infections by drug-resistant Candida albicans pose a global public health threat.
However, the pathogen's diploid genome greatly hinders genome-wide investigations of …

Many pathogenic fungi depend on the development of specialized infection structures called
appressoria to invade their hosts and cause disease. Impairing the function of fungal …

Antibiotic tolerance is the ability of a susceptible population to survive high doses of cidal
drugs and has been shown to compromise therapeutic outcomes in bacterial infections. In …

In the present study, we investigated the mechanism of cell death in C. albicans due to
treatment with sophorolipid (SL). SL is an extracellular glycolipid biosurfactant produced by …

Background This study aimed to investigate the Aspergillus species distribution, antifungal
sensitivities, clinical characteristics, and risk factors of patients with invasive aspergillosis …

Candida albicans é a espécie mais comum do gênero Candida a causar infecções
invasivas humanas. Essas infecções estão associadas a alta morbidade e alta mortalidade …