This Review is intended to help clinicians, patients, and the public make informed decisions
about statin therapy for the prevention of heart attacks and strokes. It explains how the …

Introduction Previous research has shown that statin adherence for the primary prevention of
CVD is lower compared to secondary prevention populations. Therefore the aim of this …

Statins are included in the category of high-frequency prescription drugs, and their use is on
an upward trend worldwide. In 2012, the FDA issued a warning about possible cognitive …

Starting with cholesterol homeostasis, the first part of the review addresses various aspects
of cholesterol metabolism in neuronal and glial cells and the mutual crosstalk between the …

Psychiatric adverse drug reactions (ADRs) have been reported with statin use, but the
literature regarding statin-associated mood/behavioral changes remains limited. We sought …

Extensive research has demonstrated the efficacy of the LCD to improve the most robust
CVD risk factors, such as hyperglycemia, hypertension, and atherogenic dyslipidemia. Our …

Suicide and nonfatal suicidal behaviors are major causes of mortality and morbidity
worldwide. Variability in rates of suicide and suicidal behaviors within and between …

The manner in which clinical trial investigators present their findings to healthcare providers
and the public can have a substantial influence on their impact. For example, if a heart attack …

Objectives To evaluate the risk of new-onset depression in a cohort of US adult patients
initiating lipophilic statin therapy compared to hydrophilic statin therapy. Design …

Overview: Psychiatric adverse effects, including aggression, have been reported with the
use of statin medications; however, there is little data to support or refute the theory that …