Prostate cancer is a hormone-driven disease and its tumor cell growth highly relies on
increased androgen receptor (AR) signaling. Therefore, targeted therapy directed against …

Lineage plasticity and histologic transformation to small cell neuroendocrine prostate cancer
(NEPC) is an increasingly recognized mechanism of treatment resistance in advanced …

Purpose: Neuroendocrine prostate cancer (NEPC) is a resistance phenotype that emerges
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …

Background Men with progressive neuroendocrine or aggressive-variant metastatic prostate
cancer (NEPC/AVPC) have a poor prognosis and limited treatment options, and …

Simple Summary Liquid biopsy (LB), encompassing the analysis of circulating tumor
material in the blood or urine, has emerged as a powerful tool in the management of …

Neuroendocrine differentiation (NED) is associated with WNT signaling activation and can
be significantly observed after failure of androgen-deprivation therapy (ADT) for prostatic …

The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal
cells and extracellular matrices. The TME plays important regulatory roles in tumor …

There is an urgent need for exploring new actionable targets other than androgen receptor
to improve outcome from lethal castration-resistant prostate cancer. Tumor metabolism has …

Abstract Treatment-related neuroendocrine prostate cancer is a distinctive category of
prostate cancer that arises after intensive suppression of the androgen receptor by next …

Prostate cancer is the most common cancer among men and has a high incidence and
associated mortality worldwide. It is an androgen-driven disease in which tumor growth is …