Free fatty acids (FFAs) exert both positive and negative effects on beta cell survival and
insulin secretory function, depending on concentration, duration, and glucose abundance …

Abstract Background The divalent cation Calcium (Ca 2+) regulates a wide range of
processes in disparate cell types. Within insulin-producing β-cells, increases in cytosolic Ca …

Pancreatic β cells are mostly post-mitotic, but it is unclear what locks them in this state.
Perturbations including uncontrolled hyperglycemia can drive β cells into more pliable states …

Increasing evidence indicates that long noncoding RNAs (lncRNAs) are involved in diverse
biological process. Mouse maternal expressed gene 3 (Meg3) is an imprinted gene and …

Neuronal PER-ARNT-SIM (PAS) domain protein 4 (NPAS4) is a protective transcriptional
regulator whose dysfunction has been linked to a variety of neuropsychiatric and metabolic …

Background/Aims: The islet is an important endocrine organ to secrete insulin to regulate the
metabolism of glucose and maintain the stability of blood glucose. Long noncoding RNAs …

Restoring damaged β-cells in diabetic patients by harnessing the plasticity of other
pancreatic cells raises the questions of the efficiency of the process and of the functionality …

Pancreatic β-cell mass expands during pregnancy and regresses in the postpartum period
in conjunction with dynamic metabolic demands on maternal glucose homeostasis. To …

Cytosolic calcium influx activates signaling pathways known to support pancreatic beta cell
function and survival by modulating gene expression. Impaired calcium signaling leads to …

Introduction: Type 2 diabetes mellitus (T2DM) is a chronic, complex and multifactorial
metabolic disorder, which has become a serious global health problem. The side effects of …