The immunobiology of the interleukin-12 family: room for discovery
The discovery of interleukin (IL)-6 and its receptor subunits provided a foundation to
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
understand the biology of a group of related cytokines: IL-12, IL-23, and IL-27. These family …
Intracellular pathogens: host immunity and microbial persistence strategies
A Thakur, H Mikkelsen… - Journal of immunology …, 2019 - Wiley Online Library
Infectious diseases caused by pathogens including viruses, bacteria, fungi, and parasites
are ranked as the second leading cause of death worldwide by the World Health …
are ranked as the second leading cause of death worldwide by the World Health …
T cell-mediated immunity to malaria
Immunity to malaria has been linked to the availability and function of helper CD4+ T cells,
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
cytotoxic CD8+ T cells and γδ T cells that can respond to both the asymptomatic liver stage …
The immunobiology of interleukin-27
H Yoshida, CA Hunter - Annual review of immunology, 2015 - annualreviews.org
Interleukin-27 (IL-27) is a cytokine with strikingly diverse influences on the immune
response. Although it was initially linked with the development of Th1 responses, it is now …
response. Although it was initially linked with the development of Th1 responses, it is now …
Interleukin-27: balancing protective and pathological immunity
CA Hunter, R Kastelein - Immunity, 2012 - cell.com
It has been more than 15 years since the identification of individual interleukin-27 (IL-27)
and IL-27 receptor components. The last decade has seen the description of the signaling …
and IL-27 receptor components. The last decade has seen the description of the signaling …
The role of IL-10 in malaria: a double edged sword
IL-10 produced by CD4+ T cells suppresses inflammation by inhibiting T cell functions and
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …
the upstream activities of antigen presenting cells (APCs). IL-10 was first identified in Th2 …
Early IL-6 signalling promotes IL-27 dependent maturation of regulatory T cells in the lungs and resolution of viral immunopathology
CJ Pyle, FI Uwadiae, DP Swieboda, JA Harker - PLoS pathogens, 2017 - journals.plos.org
Interleukin-6 is a pleiotropic, pro-inflammatory cytokine that can promote both innate and
adaptive immune responses. In humans with respiratory virus infections, such as …
adaptive immune responses. In humans with respiratory virus infections, such as …
Expanding diversity in molecular structures and functions of the IL-6/IL-12 heterodimeric cytokine family
H Hasegawa, I Mizoguchi, Y Chiba, M Ohashi… - Frontiers in …, 2016 - frontiersin.org
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles
in multiple immune responses. This cytokine family has very unique characteristics in that …
in multiple immune responses. This cytokine family has very unique characteristics in that …
IL-27 promotes IL-10 production by effector Th1 CD4+ T cells: a critical mechanism for protection from severe immunopathology during malaria infection
AP Freitas do Rosário, T Lamb, P Spence… - The Journal of …, 2012 - journals.aai.org
Infection with the malaria parasite, Plasmodium, is characterized by excessive inflammation.
The establishment of a precise balance between the pro-and anti-inflammatory responses is …
The establishment of a precise balance between the pro-and anti-inflammatory responses is …
The immunological balance between host and parasite in malaria
K Deroost, TT Pham, G Opdenakker… - FEMS microbiology …, 2016 - academic.oup.com
Coevolution of humans and malaria parasites has generated an intricate balance between
the immune system of the host and virulence factors of the parasite, equilibrating maximal …
the immune system of the host and virulence factors of the parasite, equilibrating maximal …