Radiotherapy is one of the most common countermeasures for treating a wide range of
tumors. However, the radioresistance of cancer cells is still a major limitation for …

All life ends in death, but perhaps one of life's grander ironies is that it also depends on
death. Cell-intrinsic suicide pathways, termed programmed cell death (PCD), are crucial for …

Cancer is a class of diseases characterized by uncontrolled cell growth and has the ability to
spread or metastasize throughout the body. In recent years, remarkable progress has been …

Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure
through direct interactions of radiation with target macromolecules or via products of water …

Salivary glands sustain collateral damage following radiotherapy (RT) to treat cancers of the
head and neck, leading to complications, including mucositis, xerostomia and …

An “abscopal” effect occurs when localized irradiation perturbs the organism as a whole,
with consequences that can be either beneficial or detrimental. Mechanistic explanations of …

There has been growing interest in the use of nanomaterials for a range of biomedical
applications over the last number of years. In particular, gold nanoparticles (GNPs) possess …

During the last decades, new radionuclide-based targeted therapies have emerged as
efficient tools for cancer treatment. Targeted radionuclide therapies (TRTs) are based on a …

The delineation of key molecular pathways has enhanced our knowledge of the biology of
tumor microenvironment, tumor dissemination, and carcinogenesis. The complexities of cell …

Non-DNA targeted effects of ionising radiation, which include genomic instability, and a
variety of bystander effects including abscopal effects and bystander mediated adaptive …