Alzheimer's disease is understood to be caused by amyloid fibrils and oligomers formed by
aggregated amyloid-β (Aβ) peptides. This review article presents molecular dynamics (MD) …

The cause of Alzheimer's disease is related to aggregates such as oligomers and amyloid
fibrils consisting of amyloid-β (Aβ) peptides. Molecular dynamics (MD) simulation studies …

We used single-molecule AFM force spectroscopy (AFM-SMFS) in combination with click
chemistry to mechanically dissociate anticalin, a non-antibody protein binding scaffold, from …

Rational design of novel antibody therapeutics against viral infections such as coronavirus
relies on surface complementarity and high affinity for their effectiveness. Here, we explore …

Amyloid beta (Aβ) oligomers are the most neurotoxic aggregates causing neuronal death
and cognitive damage. A detailed elucidation of the aggregation pathways from oligomers to …

Amyloid proteins are characterized by their tendency to aggregate into amyloid fibrils, which
are often associated with devastating diseases. Aggregation pathways typically involve …

We present a review of a series of contact maps for the determination of native interactions
in proteins and nucleic acids based on a distance-threshold. Such contact maps are mostly …

Alzheimer's disease (AD) stands as one of the most prevalent neurodegenerative
conditions, leading to cognitive impairment, with no cure and preventive measures …

Amyloid-β (Aβ) and islet amyloid polypeptide (IAPP) are small peptides, classified as
amyloids, that have the potential to self-assemble and form cytotoxic species, such as small …

The present study employs a blend of molecular dynamics simulations and a theoretical
model to explore the potential disintegration mechanism of a matured Aβ octamer, aiming to …