BRD4, member of the Bromodomain and Extraterminal (BET) protein family, is largely
acknowledged in cancer for its role in super-enhancers (SEs) organization and oncogenes …

Abstract Bromodomain‐containing 4 (BRD4), a member of Bromo and Extra‐Terminal (BET)
family, recognizes acetylated histones and is of importance in transcription, replication, and …

The epigenomic reader Brd4 is an important drug target for cancers. However, its role in cell
differentiation and animal development remains largely unclear. Using two conditional …

The human face is complex and multipartite, and characterization of its genetic architecture
remains challenging. Using a multivariate genome-wide association study meta-analysis of …

Objective Hepatocellular carcinoma (HCC), mostly developed in fibrotic/cirrhotic liver,
exhibits relatively low responsiveness to immune checkpoint blockade (ICB) therapy. As …

The endogenous repair process can result in recovery after acute kidney injury (AKI) with
adaptive proliferation of tubular epithelial cells, but repair can also lead to fibrosis and …

Cisplatin-based chemoradiotherapy is the recommended treatment for local advanced
cervical cancer, but radioresistance remains one of the most important and unresolved …

Fibrotic diseases remain a major cause of morbidity and mortality, yet there are few effective
therapies. The underlying pathology of all fibrotic conditions is the activity of myofibroblasts …

During mitosis, transcription of genomic DNA is dramatically reduced, before it is reactivated
during nuclear reformation in anaphase/telophase. Many aspects of the underlying …

Liquid–liquid phase‐separated (LLPS) transcriptional factor assemblies at super‐enhancers
(SEs) provide a conceptual framework for underlying transcriptional control in mammal cells …