Regulation of Biofilm Exopolysaccharide Biosynthesis and Degradation in Pseudomonas aeruginosa

LZ Ma, D Wang, Y Liu, Z Zhang… - Annual review of …, 2022 - annualreviews.org
Microbial communities enmeshed in a matrix of macromolecules, termed as biofilms, are the
natural setting of bacteria. Exopolysaccharide is a critical matrix component of biofilms …

Regulation of bacterial virulence by Csr (Rsm) systems

CA Vakulskas, AH Potts, P Babitzke… - Microbiology and …, 2015 - Am Soc Microbiol
Most bacterial pathogens have the remarkable ability to flourish in the external environment
and in specialized host niches. This ability requires their metabolism, physiology, and …

Global regulation by CsrA and its RNA antagonists

T Romeo, P Babitzke - Microbiology spectrum, 2018 - Am Soc Microbiol
The sequence-specific RNA binding protein CsrA is employed by diverse bacteria in the
posttranscriptional regulation of gene expression. Its binding interactions with RNA have …

Pseudomonas aeruginosa biofilm matrix polysaccharide Psl is regulated transcriptionally by RpoS and post‐transcriptionally by RsmA

Y Irie, M Starkey, AN Edwards, DJ Wozniak… - Molecular …, 2010 - Wiley Online Library
Extracellular polysaccharides are important components of biofilms. In non‐mucoid
Pseudomonas aeruginosa strains, the Pel and Psl polysaccharides are major structural …

Post‐transcriptional regulation on a global scale: form and function of Csr/Rsm systems

T Romeo, CA Vakulskas… - Environmental …, 2013 - Wiley Online Library
Originally described as a repressor of gene expression in the stationary phase of growth,
CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation …

[HTML][HTML] Diverse mechanisms and circuitry for global regulation by the RNA-binding protein CsrA

C Pourciau, YJ Lai, M Gorelik, P Babitzke… - Frontiers in …, 2020 - frontiersin.org
The carbon storage regulator (Csr) or repressor of stationary phase metabolites (Rsm)
system of Gammaproteobacteria is among the most complex and best-studied …

CsrA activates flhDC expression by protecting flhDC mRNA from RNase E‐mediated cleavage

AV Yakhnin, CS Baker, CA Vakulskas… - Molecular …, 2013 - Wiley Online Library
Csr is a conserved global regulatory system that controls expression of several hundred E
scherichia coli genes. CsrA protein represses translation of numerous genes by binding to …

The unique paradigm of spirochete motility and chemotaxis

NW Charon, A Cockburn, C Li, J Liu… - Annual review of …, 2012 - annualreviews.org
Spirochete motility is enigmatic: It differs from the motility of most other bacteria in that the
entire bacterium is involved in translocation in the absence of external appendages. Using …

Post-transcriptional global regulation by CsrA in bacteria

J Timmermans, L Van Melderen - Cellular and molecular life sciences, 2010 - Springer
Global regulation allows bacteria to rapidly modulate the expression of a large variety of
unrelated genes in response to environmental changes. Global regulators act at different …

Dual function of the McaS small RNA in controlling biofilm formation

MG Jørgensen, MK Thomason, J Havelund… - Genes & …, 2013 - genesdev.cshlp.org
Many bacterial small RNAs (sRNAs) regulate gene expression through base-pairing with
mRNAs, and it has been assumed that these sRNAs act solely by this one mechanism. Here …