Connectome-based modelling of neurodegenerative diseases: towards precision medicine and mechanistic insight

JW Vogel, N Corriveau-Lecavalier… - Nature Reviews …, 2023 - nature.com
Neurodegenerative diseases are the most common cause of dementia. Although their
underlying molecular pathologies have been identified, there is substantial heterogeneity in …

Towards a biologically annotated brain connectome

V Bazinet, JY Hansen, B Misic - Nature reviews neuroscience, 2023 - nature.com
The brain is a network of interleaved neural circuits. In modern connectomics, brain
connectivity is typically encoded as a network of nodes and edges, abstracting away the rich …

[HTML][HTML] Mapping neurotransmitter systems to the structural and functional organization of the human neocortex

JY Hansen, G Shafiei, RD Markello, K Smart… - Nature …, 2022 - nature.com
Neurotransmitter receptors support the propagation of signals in the human brain. How
receptor systems are situated within macro-scale neuroanatomy and how they shape …

[HTML][HTML] Integrating multimodal and multiscale connectivity blueprints of the human cerebral cortex in health and disease

JY Hansen, G Shafiei, K Voigt, EX Liang, SML Cox… - PLoS …, 2023 - journals.plos.org
The brain is composed of disparate neural populations that communicate and interact with
one another. Although fiber bundles, similarities in molecular architecture, and synchronized …

In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape

AI Luppi, JY Hansen, R Adapa, RL Carhart-Harris… - Science …, 2023 - science.org
To understand how pharmacological interventions can exert their powerful effects on brain
function, we need to understand how they engage the brain's rich neurotransmitter …

[HTML][HTML] Cerebral cortical structural alteration patterns across four major psychiatric disorders in 5549 individuals

J Matsumoto, M Fukunaga, K Miura, K Nemoto… - Molecular …, 2023 - nature.com
According to the operational diagnostic criteria, psychiatric disorders such as schizophrenia
(SZ), bipolar disorder (BD), major depressive disorder (MDD), and autism spectrum disorder …

[HTML][HTML] Correspondence between gene expression and neurotransmitter receptor and transporter density in the human brain

JY Hansen, RD Markello, L Tuominen, M Nørgaard… - NeuroImage, 2022 - Elsevier
Neurotransmitter receptors modulate signaling between neurons. Thus, neurotransmitter
receptors and transporters play a key role in shaping brain function. Due to the lack of …

White matter dysfunction in psychiatric disorders is associated with neurotransmitter and genetic profiles

GJ Ji, J Sun, Q Hua, L Zhang, T Zhang, T Bai… - Nature Mental …, 2023 - nature.com
Functional changes of white matter are largely unexplored in patients with psychiatric
disorders. This study examined white matter dysfunctions common in four major psychiatric …

Sensory Aspects of Restless Legs Syndrome: clinical, neurophysiological and neuroimaging prospectives.

E Antelmi, MP Mogavero, G Lanza, SM Cartella… - Sleep Medicine …, 2024 - Elsevier
Summary Restless Legs Syndrome (RLS) is a complex sensorimotor disorder, classified
among the sleep-related movement disorders. Although sensory symptoms appear as key …

[HTML][HTML] Transitions between cognitive topographies: contributions of network structure, neuromodulation, and disease

AI Luppi, SP Singleton, JY Hansen, D Bzdok… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Patterns of neural activity underlie human cognition. Transitions between these patterns are
orchestrated by the brain's network architecture. What are the mechanisms linking network …