Since it has been recognized that mitochondria are crucial not only for energy metabolism
but also for other cellular functions, there has been a growing interest in cardiolipin, the …

Among mitochondrial lipids, cardiolipin occupies a unique place. It is the only phospholipid
that is specific to mitochondria and although it is merely a minor component, accounting for …

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for
many core tasks of this organelle. Its acyl chain configurations are tissue specific …

The human nuclear and mitochondrial genomes co-exist within each cell. While the
mitochondrial genome encodes for a limited number of proteins, transfer RNAs, and …

Inflammatory bowel diseases (IBD) comprise a distinct set of clinical symptoms resulting
from chronic inflammation within the gastrointestinal (GI) tract. Despite the significant …

Cardiolipin is a specific mitochondrial phospholipid that has a high affinity for proteins and
that stabilizes the assembly of supercomplexes involved in oxidative phosphorylation. We …

Cardiolipin (CL) is a key phospholipid of the mitochondria. A loss of CL content and
remodeling of CL's acyl chains is observed in several pathologies. Strong shifts in CL …

Mitochondria, so much more than just being energy factories, also have the capacity to
synthesize macromolecules including phospholipids, particularly cardiolipin (CL) and …

Mitochondria are surrounded by the two membranes, the outer and inner membranes,
whose lipid compositions are optimized for proper functions and structural organizations of …

Barth syndrome (BTHS) is an X-linked mitochondrial lipid disorder caused by mutations in
the TAFAZZIN (TAZ) gene, which encodes a mitochondrial acyltransferase/transacylase …