Salivary gland (SG) dysfunction, due to radiotherapy, disease, or aging, is a clinical
manifestation that has the potential to cause severe oral and/or systemic diseases and …

Permanent damage to the salivary glands and resulting hyposalivation and xerostomia have
a substantial impact on patient health, quality of life, and healthcare costs. Currently, patients …

The main role of salivary glands (SG) is the production and secretion of saliva, in which
aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane …

Ionizing radiation, commonly used for head and neck cancer treatment, typically damages
the salivary glands, resulting in hyposalivation. The development of treatments to restore this …

Radiotherapy (RT) continues to play a key role in the management of head and neck cancer
(HNC). Xerostomia remains a principal detriment to the quality of life (QoL) for 80% of …

Purpose This study aims to elaborate on the current knowledge concerning the mechanism,
frequency, clinical manifestations, diagnostic procedures, prevention, and management of …

Background Radiation-induced xerostomia and oral mucositis are serious complications of
radiation therapy for head and neck cancers. Current treatment options have limited efficacy …

Cancer stem cells (CSCs) play a critical role in cancer development and growth. The aim of
this study was to identify and isolate CSCs from populations of primary oral squamous cell …

Salivary gland dysfunction worsens the quality of life, but treatment for restoration of salivary
gland function is limited. Although previous reports have demonstrated the therapeutic …

Progress in the development of salivary gland regenerative strategies is limited by poor
maintenance of the secretory function of salivary gland cells (SGCs) in vitro. To reduce the …