Insulin secretion and Ca2+ dynamics in β-cells are regulated by PERK (EIF2AK3) in concert with calcineurin
R Wang, BC McGrath, RF Kopp, MW Roe… - Journal of Biological …, 2013 - ASBMB
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)(EIF2AK3) is essential for
normal development and function of the insulin-secreting β-cell. Although genetic ablation of …
normal development and function of the insulin-secreting β-cell. Although genetic ablation of …
Calcineurin promotes neuroplastic changes in the amygdala associated with weakened cocaine-cue memories
MT Rich, YH Huang, MM Torregrossa - Journal of Neuroscience, 2020 - Soc Neuroscience
Interfering with memory reconsolidation or inducing memory extinction are two approaches
for weakening maladaptive memories in disorders such as addiction and post-traumatic …
for weakening maladaptive memories in disorders such as addiction and post-traumatic …
Vasodilatory effect of Guanxinning tablet on rabbit thoracic aorta is modulated by both endothelium-dependent and-independent mechanism
Y Ling, J Shi, Q Ma, Q Yang, Y Rong, J He… - Frontiers in …, 2021 - frontiersin.org
Vasodilatory therapy plays an important role in the treatment of cardiovascular diseases,
especially hypertension and coronary heart disease. Previous research found that …
especially hypertension and coronary heart disease. Previous research found that …
Mutated calreticulin retains structurally disordered C terminus that cannot bind Ca2+: some mechanistic and therapeutic implications
V Shivarov, M Ivanova, RV Tiu - Blood cancer journal, 2014 - nature.com
Two very recent reports 1, 2 made a tremendous breakthrough in our understanding of the
molecular basis of myeloproliferative neoplasms (MPNs) without mutations in Janus kinase …
molecular basis of myeloproliferative neoplasms (MPNs) without mutations in Janus kinase …
Chlorogenic Acids, Acting via Calcineurin, Are the Main Compounds in Centella asiatica Extracts That Mediate Resilience to Chronic Stress in Drosophila …
Common symptoms of depressive disorders include anhedonia, sleep problems, and
reduced physical activity. Drugs used to treat depression mostly aim to increase serotonin …
reduced physical activity. Drugs used to treat depression mostly aim to increase serotonin …
Kaempferol: a new immunosuppressant of calcineurin
H Wang, CL Zhou, H Lei, SD Zhang, J Zheng… - IUBMB life, 2008 - Wiley Online Library
Abstract Calcineurin (CN), the Ca2+/calmodulin (CaM)‐dependant protein phosphatase, is
the target for immunosuppressive drugs cyclosporine A (CsA) and FK506. These …
the target for immunosuppressive drugs cyclosporine A (CsA) and FK506. These …
The neuroprotective effects of ginsenosides on calcineurin activity and tau phosphorylation in SY5Y cells
LH Tu, J Ma, HP Liu, RR Wang, J Luo - Cellular and molecular …, 2009 - Springer
Calcineurin (CN) is a Ca 2+/calmodulin-dependent protein phosphatase expressed at high
levels in brain. Many findings have shown that calcineurin plays an important role in tau …
levels in brain. Many findings have shown that calcineurin plays an important role in tau …
Amoebae-Based Screening Reveals a Novel Family of Compounds Restricting Intracellular Legionella pneumophila
CF Harrison, G Chiriano, I Finsel, C Manske… - ACS infectious …, 2015 - ACS Publications
The causative agent of Legionnaires' disease, Legionella pneumophila, grows in
environmental amoebae and mammalian macrophages within a distinct compartment, the …
environmental amoebae and mammalian macrophages within a distinct compartment, the …
Inhibition of calcineurin by quercetin in vitro and in Jurkat cells
H Wang, CL Zhou, H Lei, Q Wei - Journal of biochemistry, 2010 - academic.oup.com
Abstract Calcineurin (CN), the Ca2+/calmodulin (CaM)-dependant protein phosphatase, is
an integral enzyme involved in activation of T cells. It is also the target of various inhibitors …
an integral enzyme involved in activation of T cells. It is also the target of various inhibitors …
Immunopotentiation on murine spleen lymphocytes induced by polysaccharide fraction of Panax ginseng via upregulating calcineurin activity
SD ZHANG, YANXIA YIN, Q Wei - Apmis, 2010 - Wiley Online Library
Zhang S‐D, Yin Y‐X, Wei Q. Immunopotentiation on murine spleen lymphocytes induced by
polysaccharide fraction of Panax ginseng via upregulating calcineurin activity. APMIS 2010; …
polysaccharide fraction of Panax ginseng via upregulating calcineurin activity. APMIS 2010; …