Linkers or spacers are short amino acid sequences created in nature to separate multiple
domains in a single protein. Most of them are rigid and function to prohibit unwanted …

Optical biosensor technology continues to be the method of choice for label‐free, real‐time
interaction analysis. But when it comes to improving the quality of the biosensor literature …

A necessary feature of the immune system, TCR (T-cell receptor) cross-reactivity has been
implicated in numerous autoimmune pathologies and is an underlying cause of transplant …

Abstract The RosettaBackrub server (http://kortemmelab. ucsf. edu/backrub) implements the
Backrub method, derived from observations of alternative conformations in high-resolution …

Over the past two decades, structural biology has shown how T‐cell receptors engage
peptide/major histocompatibility complex (MHC) complexes and provided insight into the …

αβ T-cell receptors (TCRs) recognize multiple antigenic peptides bound and presented by
major histocompatibility complex molecules. TCR cross-reactivity has been attributed in part …

T cells bearing receptors made up of α and β chains (TCR s) usually react with peptides
bound to major histocompatibility complex proteins (MHC). This bias could be imposed by …

The variable (V) domains of antibodies and T cell receptors (TCRs) share sequence
homology and striking structural similarity. Single-chain antibody V domain constructs (scFv) …

Abstract αβ T‐cell receptors (TCRs) recognize peptide antigens presented by class I or class
II major histocompatibility complex molecules (pMHC). Here we review the use of …

The variable domains of antibodies and T-Cell receptors (TCRs) share similar structures.
Both molecules act as sensors for the immune system but recognise their respective …