Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics
N Kumari, H Antil, S Kumari, SC Raghavan - Genomics, 2023 - Elsevier
Ligase IV is a key enzyme involved during DNA double-strand breaks (DSBs) repair through
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
nonhomologous end joining (NHEJ). However, in contrast to Ligase IV deficient mouse cells …
Depletion of RNASEH2 activity leads to accumulation of DNA double-strand breaks and reduced cellular survivability in T cell leukemia
D Ghosh, S Kumari, SC Raghavan - Journal of molecular biology, 2022 - Elsevier
Abstract Ribonuclease H2 (RNase H2) is a member of the ribonuclease H family of enzymes
involved in removal of RNA from RNA-DNA hybrids as well as ribonucleotides which get …
involved in removal of RNA from RNA-DNA hybrids as well as ribonucleotides which get …
A novel KU70-mutant human leukemic cell line generated using CRISPR-Cas9 shows increased sensitivity to DSB inducing agents and reduced NHEJ activity
KU70 (XRCC6 gene in humans) is one of the proteins in the KU70-KU80 heterodimer which
is the first component recruited to broken DNA ends during DNA double-strand break repair …
is the first component recruited to broken DNA ends during DNA double-strand break repair …
Myriad factors and pathways influencing tumor radiotherapy resistance
L Mi, H Zhang - Open Life Sciences, 2024 - degruyter.com
Radiotherapy is a cornerstone in the treatment of various tumors, yet radioresistance often
leads to treatment failure and tumor recurrence. Several factors contribute to this resistance …
leads to treatment failure and tumor recurrence. Several factors contribute to this resistance …