Microbiome engineering: synthetic biology of plant-associated microbiomes in sustainable agriculture

J Ke, B Wang, Y Yoshikuni - Trends in Biotechnology, 2021 - cell.com
To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …

Editing the genome of hiPSC with CRISPR/Cas9: disease models

AR Bassett - Mammalian Genome, 2017 - Springer
The advent of human-induced pluripotent stem cell (hiPSC) technology has provided a
unique opportunity to establish cellular models of disease from individual patients, and to …

[图书][B] Human genome editing: science, ethics, and governance

National Academies of Sciences… - 2017 - books.google.com
Genome editing is a powerful new tool for making precise alterations to an organism's
genetic material. Recent scientific advances have made genome editing more efficient …

Genome editing reveals a role for OCT4 in human embryogenesis

NME Fogarty, A McCarthy, KE Snijders, BE Powell… - Nature, 2017 - nature.com
Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy

S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …

The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency

A Bertero, S Brown, P Madrigal, A Osnato, D Ortmann… - Nature, 2018 - nature.com
The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates

BT Wesley, ADB Ross, D Muraro, Z Miao, S Saxton… - Nature Cell …, 2022 - nature.com
The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …

Regulation of translation by site-specific ribosomal RNA methylation

MD Jansson, SJ Häfner, K Altinel, D Tehler… - Nature structural & …, 2021 - nature.com
Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …

[HTML][HTML] An early cell shape transition drives evolutionary expansion of the human forebrain

S Benito-Kwiecinski, SL Giandomenico, M Sutcliffe… - Cell, 2021 - cell.com
The human brain has undergone rapid expansion since humans diverged from other great
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …

[HTML][HTML] Inducible and deterministic forward programming of human pluripotent stem cells into neurons, skeletal myocytes, and oligodendrocytes

M Pawlowski, D Ortmann, A Bertero, JM Tavares… - Stem cell reports, 2017 - cell.com
The isolation or in vitro derivation of many human cell types remains challenging and
inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression …