Microbiome engineering: synthetic biology of plant-associated microbiomes in sustainable agriculture
J Ke, B Wang, Y Yoshikuni - Trends in Biotechnology, 2021 - cell.com
To support an ever-increasing population, modern agriculture faces numerous challenges
that pose major threats to global food and energy security. Plant-associated microbes, with …
that pose major threats to global food and energy security. Plant-associated microbes, with …
Editing the genome of hiPSC with CRISPR/Cas9: disease models
AR Bassett - Mammalian Genome, 2017 - Springer
The advent of human-induced pluripotent stem cell (hiPSC) technology has provided a
unique opportunity to establish cellular models of disease from individual patients, and to …
unique opportunity to establish cellular models of disease from individual patients, and to …
[图书][B] Human genome editing: science, ethics, and governance
National Academies of Sciences… - 2017 - books.google.com
Genome editing is a powerful new tool for making precise alterations to an organism's
genetic material. Recent scientific advances have made genome editing more efficient …
genetic material. Recent scientific advances have made genome editing more efficient …
Genome editing reveals a role for OCT4 in human embryogenesis
NME Fogarty, A McCarthy, KE Snijders, BE Powell… - Nature, 2017 - nature.com
Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …
regulate the first cell fate decisions in the human embryo are not well understood. Here we …
Gene editing to prevent ventricular arrhythmias associated with cardiomyocyte cell therapy
S Marchiano, K Nakamura, H Reinecke, L Neidig… - Cell Stem Cell, 2023 - cell.com
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) offer a promising cell-
based therapy for myocardial infarction. However, the presence of transitory ventricular …
based therapy for myocardial infarction. However, the presence of transitory ventricular …
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency
The TGFβ pathway has essential roles in embryonic development, organ homeostasis,
tissue repair and disease,. These diverse effects are mediated through the intracellular …
tissue repair and disease,. These diverse effects are mediated through the intracellular …
Single-cell atlas of human liver development reveals pathways directing hepatic cell fates
The liver has been studied extensively due to the broad number of diseases affecting its vital
functions. However, therapeutic advances have been hampered by the lack of knowledge …
functions. However, therapeutic advances have been hampered by the lack of knowledge …
Regulation of translation by site-specific ribosomal RNA methylation
MD Jansson, SJ Häfner, K Altinel, D Tehler… - Nature structural & …, 2021 - nature.com
Ribosomes are complex ribozymes that interpret genetic information by translating
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …
messenger RNA (mRNA) into proteins. Natural variation in ribosome composition has been …
[HTML][HTML] An early cell shape transition drives evolutionary expansion of the human forebrain
S Benito-Kwiecinski, SL Giandomenico, M Sutcliffe… - Cell, 2021 - cell.com
The human brain has undergone rapid expansion since humans diverged from other great
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …
apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use …
[HTML][HTML] Inducible and deterministic forward programming of human pluripotent stem cells into neurons, skeletal myocytes, and oligodendrocytes
The isolation or in vitro derivation of many human cell types remains challenging and
inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression …
inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression …