Glycosaminoglycans: key players in cancer cell biology and treatment

N Afratis, C Gialeli, D Nikitovic, T Tsegenidis… - The FEBS …, 2012 - Wiley Online Library
Glycosaminoglycans are natural heteropolysaccharides that are present in every
mammalian tissue. They are composed of repeating disaccharide units that consist of either …

The alterations and roles of glycosaminoglycans in human diseases

Q Wang, L Chi - Polymers, 2022 - mdpi.com
Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Malaria biomimetic for tumor targeted drug delivery

J Pihl, TM Clausen, J Zhou, N Krishnan… - acs Nano, 2023 - ACS Publications
Malaria infected erythrocytes utilize the parasite protein VAR2CSA to bind to a unique
presentation of chondroitin sulfate (CS) for their placenta specific tropism. Interestingly …

Regenerative potential of glycosaminoglycans for skin and bone

J Salbach, TD Rachner, M Rauner, U Hempel… - Journal of molecular …, 2012 - Springer
To meet the growing need for tissue replacement materials for our aging population, the
development of new adaptive biomaterials is essential. The tissues with the highest demand …

The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

A Pudełko, G Wisowski, K Olczyk… - The FEBS Journal, 2019 - Wiley Online Library
The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

Human umbilical cord Wharton's jelly stem cell (hWJSC) extracts inhibit cancer cell growth in vitro

K Gauthaman, FC Yee… - Journal of cellular …, 2012 - Wiley Online Library
Umbilical cord mesenchymal stem cells (MSCs) have been shown to inhibit breast cancer
cell growth but it is not known whether this effect is specific to only breast cancer cells. We …

Biological functions of iduronic acid in chondroitin/dermatan sulfate

MA Thelin, B Bartolini, J Axelsson… - The FEBS …, 2013 - Wiley Online Library
The presence of iduronic acid in chondroitin/dermatan sulfate changes the properties of the
polysaccharides because it generates a more flexible chain with increased binding …

Regulation of molecular targets in osteosarcoma treatment

B Celik, K Cicek, AF Leal, S Tomatsu - International Journal of Molecular …, 2022 - mdpi.com
The most prevalent malignant bone tumor, osteosarcoma, affects the growth plates of long
bones in adolescents and young adults. Standard chemotherapeutic methods showed poor …

Proteoglycans: key partners in bone cell biology

F Lamoureux, M Baud'huin, L Duplomb… - …, 2007 - Wiley Online Library
The diversity of bone proteoglycan (PG) structure and localisation (pericellular, extracellular
in the organic bone matrix) reflects a broad spectrum of biological functions within a unique …

Oversulfated chondroitin sulfate‐E binds to BMP‐4 and enhances osteoblast differentiation

T Miyazaki, S Miyauchi, A Tawada… - Journal of cellular …, 2008 - Wiley Online Library
Small leucine‐rich proteoglycans, such as biglycan, and their side chain sulfated
glycosaminoglycans (GAGs), have been suggested to be involved in bone formation and …