Metabolic homeostasis in mammals is tightly regulated by the complementary actions of
insulin and glucagon. The secretion of these hormones from pancreatic β-cells and α-cells …

The pancreas is made from two distinct components: the exocrine pancreas, a reservoir of
digestive enzymes, and the endocrine islets, the source of the vital metabolic hormone …

Endocrine cells within the pancreatic islets of Langerhans are heterogeneous in terms of
transcriptional profile, protein expression and the regulation of hormone release. Even …

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate
systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell …

Pancreatic β-cells form highly connected networks within isolated islets. Whether this
behaviour pertains to the situation in vivo, after innervation and during continuous perfusion …

Pancreatic beta cells are the only cell type in our body capable of producing and secreting
insulin to instruct the insulin-sensitive cells and tissues of our bodies to absorb nutrients after …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying
mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We …

Pancreatic beta cells have been shown to be heterogeneous at multiple levels. However,
spatially interrogating transcriptional heterogeneity in the intact tissue has been challenging …

Diabetes is a multifactorial disorder characterized by loss or dysfunction of pancreatic β-
cells. β-cells are heterogeneous, exhibiting different glucose sensing, insulin secretion and …