The neuropathogenesis of AIDS

F González-Scarano, J Martín-García - Nature reviews immunology, 2005 - nature.com
HIV-associated dementia (HAD) is an important complication of the central nervous system
in patients who are infected with HIV-1. Although the incidence of HAD has markedly …

The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex

RW Price, B Brew, J Sidtis, M Rosenblum, AC Scheck… - Science, 1988 - science.org
Infection with human immunodeficiency virus type 1 (HIV-1) is frequently complicated in its
late stages by the AIDS dementia complex, a neurological syndrome characterized by …

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

PJ Maddon, AG Dalgleish, JS McDougal, PR Clapham… - Cell, 1986 - cell.com
The isolation of clones encoding the human surface protein T4, and the expression of the T4
gene in new cellular environments, have enabled us to examine the role of this protein in the …

The AIDS dementia complex: II. Neuropathology

BA Navia, ES Cho, CK Petito… - Annals of Neurology …, 1986 - Wiley Online Library
In order to define the histopathological substrate of the dementia that frequently complicates
the acquired immune deficiency syndrome (AIDS), we analyzed the neuropathological …

Immortalization of primary microglia: a new platform to study HIV regulation in the central nervous system

Y Garcia-Mesa, TR Jay, MA Checkley, B Luttge… - Journal of …, 2017 - Springer
The major reservoirs for HIV in the CNS are in the microglia, perivascular macrophages, and
to a lesser extent, astrocytes. To study the molecular events controlling HIV expression in the …

Dual infection of the central nervous system by AIDS viruses with distinct cellular tropisms

Y Koyanagi, S Miles, RT Mitsuyasu, JE Merrill… - Science, 1987 - science.org
Human immunodeficiency virus (HIV) is the causative agent of the acquired immune
deficiency syndrome (AIDS). A large number of AIDS patients show evidence of neurologic …

Modeling and analyzing HIV transmission: the effect of contact patterns

JA Jacquez, CP Simon, J Koopman, L Sattenspiel… - Mathematical …, 1988 - Elsevier
A compartmental model is presented for the spread of HIV in a homosexual population
divided into subgroups by degree of sexual activity. The model includes constant recruitment …

Progressive multifocal leukoencephalopathy in 47 HIV-seropositive patients: neuroimaging with clinical and pathologic correlation.

ML Whiteman, MJ Post, JR Berger, LG Tate, MD Bell… - Radiology, 1993 - pubs.rsna.org
The authors investigated the spectrum of radiologic findings in a large series (n= 47) of
patients seropositive to human immunodeficiency virus (HIV) 1 and with pathologically …

HIV‐1 infection of subcortical astrocytes in the pediatric central nervous system

C Tornatore, R Chandra, JR Berger, EO Major - Neurology, 1994 - AAN Enterprises
Early reports of pediatric HIV-1-associated neuropathology described the presence of viral
particles in some astrocytes, implicating direct infection of the immature nervous system as a …

Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide

DE Brenneman, GL Westbrook, SP Fitzgerald… - Nature, 1988 - nature.com
The clinical manifestations of AIDS (acquired immune deficiency syndrome) often include
neuropsychiatric and neurological deficits1–4, including early memory loss and progressive …