Chronic pain is associated with abnormal excitability of the somatosensory system and
remains poorly treated in the clinic. Potassium (K+) channels are crucial determinants of …

Manipulation of neurotrophin (NT) signalling by administration or depletion of NTs, by
transgenic overexpression or by deletion of genes coding for NTs and their receptors has …

Sensory abnormalities generated by nerve injury, peripheral neuropathy or disease are
often expressed as neuropathic pain. This type of pain is frequently resistant to therapeutic …

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat.
Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely …

Neuropathic pain is a severe health problem for which there is a lack of effective therapy. A
frequent underlying condition of neuropathic pain is a sustained overexcitability of pain …

Significance: Reactive oxygen and nitrogen species (ROS and RNS, respectively) can
intimately control neuronal excitability and synaptic strength by regulating the function of …

Dysfunctional dopamine signaling is implicated in various neuropsychological disorders.
Previously, we reported that dopamine increases D1 receptor (D1R)-expressing medium …

NGF is a well-known neurotrophic factor essential for the survival and maintenance of
primary afferent neurons and sympathetic neurons. NGF is also an inflammatory mediator …

Neurohumoral activation is an early hallmark of cardiovascular disease and contributes to
the etiology of the pathophysiology. Stellectomy has reemerged as a positive therapeutic …

The Spontaneously Hypertensive Rat (SHR) has increased sympathetic drive to the
periphery that precedes and contributes to the development of high blood pressure, making …