Genomic DNA is folded into loops and topologically associating domains (TADs), which
serve important structural and regulatory roles. It has been proposed that these genomic …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

The cohesin complex topologically encircles DNA to promote sister chromatid cohesion.
Alternatively, cohesin extrudes DNA loops, thought to reflect chromatin domain formation …

Condensin is a structural maintenance of chromosomes (SMC) complex family member
thought to build mitotic chromosomes by DNA loop extrusion. However, condensin variants …

Loop extrusion has emerged as a prominent hypothesis for how SMC complexes shape
chromosomes–single molecule in vitro observations have yielded fascinating images of this …

Eukaryotic chromosomes compact during mitosis into elongated cylinders—and not the
spherical globules expected of selfattracting long flexible polymers. This process is mainly …

Condensin I is a five-subunit protein complex that is central to mitotic chromosome assembly
in eukaryotic cells. Despite recent progress, its molecular mechanisms of action remain to be …

3D chromatin organization plays a critical role in regulating gene expression, DNA
replication, recombination, and repair. While initially discovered for its role in sister …

Single-molecule detection-based super-resolution microscopy (SMDSRM) has enabled
researchers to analyze single-cells with resolution of colorful image in tens of nanometer …

For accurate mitotic cell division, replicated chromatin must be assembled into
chromosomes and faithfully segregated into daughter cells. While protein factors like …