While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

The advent of SELEX (systematic evolution of ligands by exponential enrichment)
technology has shown the ability to evolve artificial ligands with affinity and specificity able to …

Beyond traditional needs of biosensors such as high sensitivity and selectivity for analyte
detection, newly emerging requirements including a real-time detection ability and in-field …

Modified nucleic acids, also called xeno nucleic acids (XNAs), offer a variety of advantages
for biotechnological applications and address some of the limitations of first-generation …

In the last three decades, oligonucleotides have been extensively investigated as probes,
molecular ligands and even catalysts within therapeutic and diagnostic applications. The …

Nucleic acid aptamers are ssDNA or ssRNA fragments that specifically recognize targets.
However, the pharmacodynamic properties of natural aptamers consisting of 4 naturally …

DNA‐encoded library (DEL) technologies are transforming the drug discovery process,
enabling the identification of ligands at unprecedented speed and scale. DEL makes use of …

Threose nucleic acid has been considered a potential evolutionary progenitor of RNA
because of its chemical simplicity, base pairing properties and capacity for higher-order …

Nucleic acid aptamers selected through systematic evolution of ligands by exponential
enrichment (SELEX) fold into exquisite globular structures in complex with protein targets …

In the past three decades, in vitro systematic evolution of ligands by exponential enrichment
(SELEX) has yielded many aptamers for translational applications in both research and …