The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs)
has the potential to provide an unlimited source of insulin-producing β cells for the treatment …

Our understanding of diabetes mellitus has benefited from a combination of clinical
investigations and work in model organisms and cell lines. Organoid models for a wide …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), yet the low donor
pool, poor islet engraftment, and life-long immunosuppression prevent it from becoming the …

Intrahepatic islet transplantation is the standard cell therapy for β cell replacement. However,
the shortage of organ donors and an unsatisfactory engraftment limit its application to a …

Biomaterials, biomedical devices and engineered cell grafts can be implanted to restitute
tissue anatomy and function. Such implants can either integrate physiologically, with no or …

Traditional cell lines and xenograft models have been widely recognized and used in
research. As a new research model, organoids have made significant progress and …

Adult organs are vascularized by specialized blood vessels. In addition to inter-organ
vascular heterogeneity, each organ is arborized by structurally and functionally diversified …

Intrahepatic islet transplantation is a promising β-cell replacement strategy for the treatment
of type 1 diabetes. Instant blood-mediated inflammatory reactions, acute inflammatory storm …

Islet transplantation represents an effective treatment for patients with type 1 diabetes
mellitus (T1DM) and severe hypoglycaemia unawareness, capable of circumventing …

Islet transplantation may provide a prospective treatment for type 1 diabetes. To enable islet
transplantation and restore autonomous glucose monitoring and insulin secretion, islets or β …