During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

The spindle checkpoint ensures proper chromosome segregation during cell division.
Unravelling checkpoint signalling has been a long-standing challenge owing to the …

In the dividing eukaryotic cell, the spindle assembly checkpoint (SAC) ensures that each
daughter cell inherits an identical set of chromosomes. The SAC coordinates the correct …

The spindle assembly checkpoint (SAC) is the major surveillance system that ensures that
sister chromatids do not separate until all chromosomes are correctly bioriented during …

Regulation of macromolecular interactions by phosphorylation is crucial in signaling
networks. In the spindle assembly checkpoint (SAC), which enables errorless chromosome …

Error-free chromosome segregation relies on stable connections between kinetochores and
spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections …

BubR1 is a central component of the spindle assembly checkpoint that inhibits progression
into anaphase in response to improper kinetochore–microtubule interactions. In addition …

The mitotic checkpoint complex (MCC) coordinates proper chromosome biorientation on the
spindle with ubiquitination activities of CDC20-activated anaphase-promoting …

The spindle assembly checkpoint (SAC) monitors and promotes kinetochore–microtubule
attachment during mitosis. Bub1 and BubR1, SAC components, originated from duplication …

The mitotic checkpoint evolved to prevent cell division when chromosomes have not
established connections with the chromosome segregation machinery. Many of the …